Biophysics / Internet Invited Lecture

THE USE OF A LOW COHERENCE SOURCE FOR RAPID NEAR-INFRARED DIFFUSE OPTICAL TOMOGRAPHY AND ENDOSCOPIC NEAR-INFRARED OPTICAL TOMOGRAPHY

Daqing Piao
School of Electrical and Computer Engineering
Oklahoma State University
Stillwater, Oklahoma, USA

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ABSTRACT

Low coherence source has been extensively used in optical low coherence interferometry and optical coherence tomography for high-resolution biological imaging. In this work, low coherence source is demonstrated for the use in near-infrared diffuse optical tomography to acquire high contrast images of biological tissues. The spectral bandwidth of the low coherence source was dispersed by a grating and coupled to linearly bundled fibers. The one-dimensional spatial distribution of the source spectrum on the fiber facet plane formed a “spread” spectral-encoding among the bundled fibers, which could be used for parallel source illumination onto tissue for near-infrared diffuse optical tomography. The detection of spread-spectral-encoding signals by spectrometer allowed simultaneous sampling of all source-detector pairs for rapid NIR optical tomography. Furthermore, the use of linear fiber bundle for light delivery enabled the arrangement of multiple source/detector channels inside a small circular probe for endoscopic implementation of NIR optical tomography. A 20mW superluminescent diode centered at 840nm with 40nm bandwidth was used as the source. A sampling speed of 5Hz was obtained in a 27mm conventional circular imaging array consisting of 8 sources and 8 detection channels. A sampling speed of 8Hz was achieved with a 12mm endoscopic transverse imaging probe consisting of 8 sources and 8 detection channels. Imaging results from phantoms and tissues are presented. This technique opens a new application of the low coherence source like superluminesceint diode in biological imaging.

Representing Author:

Daqing Piao, Oklahoma State University, Assistant Professor (Stillwater, Oklahoma, USA)

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DEDICATION:

SFM 2006 is dedicated to the memory of Professor Mark L. Katz on the 100 anniversary of his birth and the 60th anniversary of the Chair of Optics and Biomedical Physics founded by him in 1946 in Saratov State University.