Biophysics / Internet Invited Lecture
ENHANCEMENT OF REPRODUCIBILITY OF BLOOD GLUCOSE SENSING USING TWO-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY
Roman Kuranov, Donald Prough, Veronika Sapozhnikova, Inga Cicenaite, Thomas Wegeng, Rinat Esenaliev, University of Texas Medical Branch, Galveston, TX, USA
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DiscussionABSTRACT
Continuous non-invasive blood glucose monitoring is of a great significance for management of diabetes and critically ill patients. Various absorption and scattering based optical methods have been proposed for this purpose. Although promising results have been demonstrated in in vitro studies, in vivo reproducibility of glucose monitoring is limited. Recently we have proposed the use of Optical coherence tomography (OCT) to monitor blood glucose level in vivo. In this study we tested the reproducibility of in vivo blood glucose monitoring with the OCT technique.
By increasing the number of averaged A-scans up from 2100 to 8400, we improved prediction of blood glucose concentration from 3mM down to 2mM.
The osmotic mechanism for glucose-induced changes in OCT signal slope, which we have been studied recently, may explain incomplete restoration of interstitial water content in skin after first glucose injection that results in lesser actual amplitude of the second peak compared to the predicted value.
Representing Author:
Roman V. Kuranov, UTHSCSA, Instructor/Research (San Antonio, USA)
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